Coffee is one of the most popular beverages in the world, but not everyone enjoys it. Some people find coffee to be too bitter, while others experience negative side effects such as anxiety, insomnia, and headaches.

A growing body of research suggests that our sensitivity to caffeine is largely determined by our genes. One gene, CYP1A2, plays a particularly important role in caffeine metabolism. People with two copies of the “fast” variant of CYP1A2 metabolize caffeine quickly and are less likely to experience negative side effects. People with two copies of the “slow” variant of CYP1A2 metabolize caffeine slowly and are more likely to experience negative side effects.

In addition to genetics, other factors such as age, weight, and lifestyle can also affect caffeine sensitivity. For example, pregnant women and people who are taking certain medications may be more sensitive to caffeine.

For people who are sensitive to caffeine, there are a few things they can do to reduce their intake and avoid negative side effects. One is to limit their consumption of coffee and other caffeinated beverages. Another is to choose decaffeinated coffee or tea. People can also try drinking coffee earlier in the day to avoid disrupting their sleep.

If you are concerned about your caffeine sensitivity, it is important to talk to your doctor. They can help you determine if caffeine is contributing to any health problems you are experiencing and can provide advice on how to manage your caffeine intake.

Tips for people with coffee sensitivity:

• Limit your intake of coffee and other caffeinated beverages.
• Choose decaffeinated coffee or tea.
• Drink coffee earlier in the day.
• Talk to your doctor about your caffeine sensitivity and how to manage it.