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Japanese researchers have found that chlorogenic acid — a natural compound found in coffee — can reduce gum inflammation and decrease bacteria associated with periodontitis.

The results were published in Dentistry Journal, a leading international dental journal emphasizing high-quality, innovative research with impact on clinical practice, scientific developments, and policy worldwide.

Periodontitis develops due to chronic gum inflammation and destruction of the tissues supporting teeth, which in severe cases can lead to tooth loss.

The primary driver is dental plaque — a bacterial biofilm that changes composition over time and accumulates pathogenic microorganisms.

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These bacteria are difficult to remove with standard hygiene, and dense biofilms are challenging even for professional cleaning.

The researchers investigated whether chlorogenic acid could improve the control of inflammation and pathogenic bacteria.

Laboratory experiments on gum tissue samples and extracted teeth from periodontitis patients assessed the effect on inflammatory markers and microbial growth.

Results showed that chlorogenic acid suppresses pro-inflammatory cytokines, including interleukin‑1β and interleukin‑8, and reduces the proliferation of bacteria such as Streptococcus mutans, Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, and Fusobacterium nucleatum.

According to the authors, the compound exhibits strong anti-inflammatory and antibacterial properties and may serve as a promising adjunct for the prevention and treatment of periodontitis.

This study represents an example of translational research, where laboratory findings could be applied in future clinical practice. However, as the experiments were conducted in vitro, further trials are needed to confirm clinical effectiveness.

dentistry

Japanese Scientists: Coffee Protects Gums from Inflammation